Lime Street station could be shut down for up to two months while major improvement work is carried out.
Network Rail, who maintain the station, have confirmed the closure is likely in 2017 or 2018 as part of a £1bn investment in the north of England railway system.
The proposed work will see an additional platform at Lime Street and improve the layout of platforms across the station to improve flexibility, maximising train access to the station and making provision for longer trains to stop.
Network Rail say that adding an additional platform will support an increase in passenger numbers from the current 20 million people a year who pass through the station.
There will also be wider platforms to provide safer access to trains with improved capacity providing the potential for three extra services per hour.
A spokesman for Network Rail said: “Our plans are constantly reviewed so we are focused on minimising disruption and maximising benefits to passengers.
“This work will not take place in 2016 and we are working with stakeholders in Liverpool to plan the best time to carry out these improvements in 2017 or 2018.”